What Is PGS Or Pre-implantation Genetic Screening?

PGS or Pre-implantation Genetic Screening is utilized to identify the cells present in an embryo and confirm if the number of chromosomes is normal (46). When an embryo develops in the lab, it typically grows into a blastocyst by day 5. A small number of cells are extracted and tested to ensure genetic normalcy. Embryos that have a normal number of chromosomes are called "euploid," and those with abnormalities are called "aneuploid." The objective of PGS is to prevent the transfer of an abnormal embryo inside the uterus.

Things You Should Know About PGS

Pre-implantation genetic screening (PGS) testing is widely utilized in the IVF cycle. Here are a few facts you should know if you are thinking of IVF treatment.

Not Suitable For Everyone

Not Suitable For Everyone

It is a noticeable thing that PGS treatment is an efficient method to search for the best quality embryo for transfer, but it is not suitable and suggested for everyone. It is mostly recommended for couples who have gone through unsuccessful IVF cycles and multiple miscarriages.

PGS vs PGD

PGS vs PGD

PGS doesn't inspect for a particular ailment, but PGD can test. Pre-implantation Genetic Diagnosis (PGD) inspects embryos for particular genetic diseases. PGD is used if you have a previous record of genetic diseases in your family.

Chromosome Abnormalities

Identifies Chromosome Abnormalities

PGS inspects the accurate count of chromosomes. There can be abnormalities such as rare chromosomes and excessive chromosomes which are called aneuploidy. These abnormalities are answerable for Down syndrome and majority of miscarriages.

Unsuccessful IVF

Helps with Unsuccessful IVF

Unsuccessful IVF cycles and miscarriages are generally the results of abnormalities in chromosomes. The current study has shown that testing embryos through PGS ensures normal chromosomes, leading to a significant reduction in miscarriages.

Biopsy Concerns

Biopsy Concerns

When it classifies the embryo with a high number of normal chromosomes, there is also a shortcoming: a slight injury might happen when the embryo is biopsied to release cells for inspection, though advanced techniques keep this risk minimal.

Mosaicism

Understanding Mosaicism

A state called mosaicism exists in which some of the normal cells can contain abnormal cells, and some of the abnormal cells might contain a normal cell. This can affect the accuracy of the chromosome's position of the embryo in the report.

Who Should Consider PGS?

In short, PGS examines the correct number of normal chromosomes. This screening is useful for many patients as it has improved pregnancy rates and eliminates the threat of miscarriage.

Multiple IVF Failures

PGS test improves the chances of healthy embryo transfer by determining the right number of normal chromosomes. Eventually, it will increase the possibility of a successful pregnancy and reduce the requirement of multiple IVF cycles.

Recurrent Miscarriages

Ultimately when PGS is identifying the healthy chromosomes in the embryos, the chances of successful pregnancy naturally increase. It also eliminates the possibility of miscarriages which usually happen because of abnormal chromosomes.

Age Above 35 Years

Renowned research and facts tell that women above 35 years old have more possibility of infertility, miscarriages and Down syndrome. The chances of abnormal chromosomes present in embryos increase with age.

Severe Male Factors

Couples who are opting for IVF treatment might choose PGS because there might be severe male infertility factors associated with it, or for those couples who might have the serious tension of passing on a genetic disease.

Ready to Take the Next Step?

Because clarity brings confidence-and confidence leads to the right decisions. At India IVF, our fertility specialists take the time to listen, understand your journey, and guide you honestly about whether PGS is the right choice for your treatment.

Who can get the most benefits from PGS?

Every couple that is undergoing IVF treatment has a risk of miscarriage and failed pregnancy. Low quality or abnormal embryos are mainly responsible for this. To maximize the importance of success, euploid (normal chromosome) pregnancy is crucial.

Maximize IVF Success

PGS is highly beneficial for couples who have experienced multiple failed IVF attempts. By ensuring only genetically normal embryos are selected for transfer, the chances of a successful implantation and healthy pregnancy increase significantly.

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Reduce Miscarriage Rates

The utilization of PGS has increased a lot because it has been recommended by many doctors and patients who desire to get normal pregnancy through normal embryo transfer, ultimately minimizing the painful experience of recurrent miscarriages.

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Prevent Genetic Issues

For couples who have serious tension of passing on a genetic disease, PGS/PGD serves as a major medical advancement. It allows for the screening of embryos before implantation, securing the future health of your baby.

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Learn More About PGS

Expert insights on how PGS can help you achieve a healthy pregnancy.

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Questions About PGS Testing

Understanding your fertility options is the first step toward hope. These are the questions fertility specialists at India IVF answer every day-so you can move forward with clarity, confidence, and informed decisions.

PGS (Pre-implantation Genetic Screening) checks for the overall number of chromosomes to ensure there are 46, helping prevent issues like Down syndrome or miscarriages. PGD (Pre-implantation Genetic Diagnosis) is used to test for specific inherited genetic diseases (like Cystic Fibrosis or Sickle Cell Anemia) when parents are known carriers.
While highly accurate (often 98-99%), no medical test is 100% perfect. There is a small phenomenon called "mosaicism," where an embryo might have a mix of both normal and abnormal cells, which can sometimes complicate the results. Your specialist will guide you clearly on interpreting the reports.
With modern techniques, the risk of harming the embryo during a day-5 blastocyst biopsy is extremely low (less than 1%). The cells are taken from the trophectoderm (which becomes the placenta), leaving the inner cell mass (which becomes the baby) completely untouched.

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