These eggs are fertilized in the laboratory after the surgeon retrieved the eggs from an ovary (follicular aspiration). This is performed through intracytoplasmic sperm injection (ICSI) or a simple in vitro fertilization (IVF).
After fertilization, an egg begins to split and build up into an embryo instantly.
Let’s know the stages of development
First-day stage, the pronuclear stage (fertilized egg)
The second-day stage (the two to four-cell)
The third-day stage (the eight-cell stage)
The fourth-day stage (the morula stage)
The fifth day(Blastocyst stage)
The surgeon infiltrates one or more embryos in the female’s uterus after egg removal within 2 to 3 days. This process is known as Blastocyst Embryo Transfer and that is what we are talking about.
The embryos can also buildup in the fifth day or Blastocyst stage and it generally happens because of improved cell culture media (blastocyst culture transfer).
Different advantages of blastocyst transfer are described below
It is possible to identify embryos with development potential
You will be surprised to know that only 20 to 30% of eggs can be developed into a blastocyst. In the event, embryo successfully converted to the blastocyst then there is a greater chance of implantation.
The right time of blastocyst transfer in IVF
It generally takes nearly 5 days after embryo fertilization contact uterine void, where it can be planted. The inside layer of the uterus supposed to be accessible on this day.
Well, A blastocyst transfer, is a method integrated with in vitro fertilization (IVF), crafted to get success in pregnancy rates and eliminate the risk of multiple pregnancies. This method of treatment is initiated by researchers from Australia. As per their report, the chosen patients who have been treated by this method reported having been pregnancy rate(blastocyst transfer success rates) higher and almost double. However, it also eradicates the highly sequential multiple pregnancies such as triplets or quadruplets.
A blastocyst embryo enters the development phase that needs the launch of the embryo’s gene known as genomic activation. The gene of a person tells about his/her identity of heredity and it makes them unique from one another. In simple words, when a woman egg and male sperm are fertilized with each other consequently a child is a combination of mother and father genes. The combination of genes generates a child who is different and unique from after, mother and siblings. For the duration of the early stage of embryo development, every chemical and force needed to cell splitting up arrive from the mother’s egg. To carry on to the development of after 4th and 5th day of life, the embryo necessarily makes active its own gene to create energy for future cell division and separation. However, this biological process is complicated and it might be not as simple as we think. Nearly only 1/3rd of embryos are competent in fruitfully making their genes active and developed into the blastocyst stage. If an embryo manages to enter the blastocyst stage, it means it is the healthier embryo and it has a great percentage of successful implantation and results in a healthy and normal baby.
In traditional IVF treatment, embryos are developed for only 2-3 days prior to infiltrating inside the uterus. Generally, embryos contain 4 to 8 cells within the shell (zona pellucida). And they mandatorily carry on their development and growth into the uterus for more than 4-5 days prior to entering in the blastocyst stage. If somehow a couple has the capability to generate multiple embryos, it would be difficult for an embryologist to detect the capable blastocyst embryo to enter the uterus. Choosing a collection of embryos for uterine infiltration (embryo transfer) 2 or 3 days after ovulation, it would be uncertain to identify which of these embryos is able to become a blastocyst embryo. That is the reason; traditional IVF treatment is generally performed by transferring 2-3 embryos. It is not easy to decide which of these embryos are having a chance of implantation, but detecting that maybe one or two embryos has the capability to become blastocyst and result in a normal pregnancy. IVF center restores embryos in IVF lab for the next 2-3 days and that enables these embryos to reach blastocyst development. Eventually, it will give green signal to the IVF doctor for embryo replacement and the healthy pregnancy can take place easily after that. The success of blastocyst transfer twin rate depends upon the healthy embryos and implantation in the form of the blastocyst.
Why Blastocyst Transfers are not ideal for everyone?
To achieve success in blastocyst not the cup of tea for every IVF treatment center of the laboratory. There are rare IVF clinics that can perform blastocyst culture transfer easily like India IVF because we have expertise and experience in this specific treatment. We have a team of veteran embryologists as they have the capability to grow the chances of pregnancy in a significant manner and reducing the risk of multiple pregnancies. One thing is very important to clarify that blastocyst transfer doesn’t convert any inferior quality to a fertilized embryo, on the other hand only high-quality embryos can become the blastocyst embryo. There might be few couples who usually don’t have high-quality embryos. So in such cases, blastocyst culture transfer permits IVF specialists to analyze these embryos’ development and detect the cause for the failure of previous treatment. There are also many couples who don’t have the capability to produce embryos that fruitfully become the blastocyst embryo, and the transfer is such an embryo can be postponed when it is denying to grow usually. This piece of information might be beneficial for couples who are searching for other alternatives to get their dream of becoming parents.
Why Blastocyst Transfer Have a Higher Implantation Rate as compared to Day Two to Four Stage?
Well, not every fertilized embryo is normal, which means there are a percentage of successful pregnancy rates. The large numbers of such complications are chromosomal. It has been found that nearly 25 percent of eggs are chromosomally incompetent, and this problem grows with the age of a woman. The result of this is that several incompetent embryos decline to grow at the time of development. Hence by choosing the blastocyst stage, a patient has already won half of the battle, because only capable embryos can reach the blastocyst stage. That is a blastocyst transfer has a greater possibility of forming a child after it is infiltrated to the patient. Study and information collected on the blastocyst transfer on 5to 6 days show that the pregnancy rates are double as compared to the split-phase of embryos has been recorded.
The other significant reason for higher implantation success rates in blastocyst transfer is that it is the development stage of embryos. That will infiltrate and accommodate in the uterus at implantation. As the situation inside the uterus and fallopian tube fluctuates, blastocyst embryos are able to stay alive and develop in the uterus. In the result of that, an improved and uniformly fruitful pregnancy via blastocyst transfer is accomplished with fewer embryos and eliminates the risk of multiple pregnancies.