About Third Party Reproduction
When the husband/partner lack any sperms or have a very poor semen analysis (azoospermia, oligospermia, poor motility), Couples go for donor sperm (DI). Sperm donation is also an option when there is a genetic problem that is inherited. Single women who want a child biologically also go for DI. You should be psychologically ready to go for DI. it is highly recommended that any patient who is seriously considering DI should see a counsellor who is experienced giving the right counselling infertility, and about trying DI. It is necessary that both partners should be comfortable to openly discuss the fears and questions. For many, it might mean dealing with certain questions of moral and ethical importance. for others it may be searching for questions about donor selection and whether to let the child conceived to know how they were conceived.
Donor selection includes information relating to a donor’s physical characteristics, which may be educational qualifications, career history, race, ethnic background, and overall health. Many banks give written profiles about the donors and some sperm banks are even provides non-identifiable knowledge about the donor (including photographs) as well as gives a service for adult offspring to get the information about the donor.
Everyone who is a donor must go for certain tests for infections such as gonorrhoea, chlamydia, streptococcal species, syphilis, hepatitis B, cytomegalovirus (CMV), and trichomonas. All these infections can easily spread via semen to a woman. Some of these infections have a great effect on the fetus; while others affect the woman greatly. The donor’s semen needs to be checked for the appearance of white blood cells which can symbolise an underlying infection within the reproductive tract.
Certain types of donors are excluded from a donor program when he or his sexual partner are experiencing any of the following: a history of homosexual activity, a blood transfusion within one year, having various sexual partners, a history of drug use through IV use or a history of genital herpes.
Before starting DI, a thorough medical and reproductive history needs to be taken on the woman and other tests blood type, rubella titer, an antibody test for CMV also should be carried out. If the woman’s tests come out for negative for CMV, then a CMV-negative donor should only be used for such procedure.
The DI procedure requires insemination of the woman closer to the time of ovulation as possible
The highest success rates for this procedures are found in women suffering from no infertility issues and are below 35 years of age and only the partner/husbands have azoospermia (no sperm). The success rates become much lower where there is a female factor like ovulation problem, endometriosis, DES is involved or the woman is above the age of 35.
Success rates range from 60-80% for this procedure but getting pregnant may take many cycles.
If your age is above 40 or you are unable to produce any healthy eggs, donor eggs will help you carry and deliver a healthy baby. This is also considerd to be the best option when there is a risk of passing a genetic disease like Tay-Sachs disease or sickle cell anaemia to the offspring.
Treatment: What to expect
If you want to go for an unknown egg donor, you can find her easily through our fertility clinic. You can choose her considering her physical attributes, ethnic history, educational record, and job. Most donors that are chosen are usually between 21 and 29 years old and have to mental, medical, and genetic screening. You must know how your clinic selects candidates ” some perform less extended tests and background checks as compared to the others. If you choose to use donor embryos, you can either select a separate egg and sperm donors or make use of a frozen embryo provided by a couple that had extras.
Once picked a donor,it is advised for you and her to take birth control pills in order to sync your reproductive cycles” she has to ovulate only when your uterine lining is ready to support an embryo. She’ll also be given a fertility drug in order to help her produce several mature eggs for fertilization. Meanwhile, you will also receive estrogen and progesterone for preparing your uterus for pregnancy. Once the eggs are mature, an anaesthetic will be given to her for removing the eggs from her ovaries through the insertion of a needle through her vaginal wall with the help of an ultrasound for guidance.
After this, the whole procedure becomes just like that of in vitro fertilization (IVF). The sperm of your partner’s or a donor’s sperm will be merged with your donor’s eggs in a Petri dish in a laboratory. After two to five days, every fertilized egg will become a mass of cells called an embryo. Your doctor then will place two to four embryos into your uterus via your cervix with the help of a thin catheter. Despite it not being a common practice, many experts suggest couples should think of transferring a single embryo to circumvent the risk of multiple pregnancies. Extra embryos, if any, might be frozen in case of failure of this cycle. If the treatment succeeds an embryo will attach in your uterine wall and continue to become an offspring. In about 40 per cent of ART pregnancies that are done with donor eggs, more than one embryo becomes implanted by itself and women give birth to twins or triplets.
We at our clinic will help you out in estimating the advantages of gestational surrogacy and give you the information regarding cost, treatment protocols and legal issues. In the case of traditional surrogacy, the surrogate has her own biological child in her womb, but this child gets raised by others. In gestational surrogacy, the surrogate mother becomes pregnant with the method of embryo transfer and gets pregnant with a child that is not biologically related to her. The surrogate mother is thus only the gestational carrier. Once a fit surrogate has been recognised, and the screening method is finished, the cycle can initiate. The timing for this cycle depends on the surrogates and expected parents/donors menstrual cycle.
Surrogacy Cycle Overview
The surrogate’s uterus must be prepared for implantation with natural estrogen and progesterone. As we know that every woman is different from the other, thus the duration, dose, and method of giving these hormones may need to be personalized. This can be determined in advance by carrying out an evaluation cycle. This refers to an â€œdry runâ€ where we copy every portion of the cycle except the real transfer process of embryos for learning how to maximize the odds of success. The evaluation cycle is accomplished anytime before the original procedure. Under certain circumstances, the evaluation cycle can be dismissed when the response of the uterus to hormonal stimulation is known quite well. This is quite common for women undergoing various treatment cycles in the past.
It is required to synchronize the menstrual cycles of the surrogate and the expected parent for getting the mature eggs and embryos and transfer these back into a flawlessly prepared uterine lining for increasing the chances of successful pregnancy This is done with the help of hormonal guidance.We rule out the best technique that works best for every situation. Once both surrogate and expected parent ovarian function are suppressed and their cycles synchronized, they can begin the process of preparing for pregnancy.
On the same day, both the expected parent and the surrogate and begins the hormonal therapies to prepare the appropriate target for pregnancy success. The surrogate will start taking estrogen to spur the endometrial growth and the intended parent will also start taking FSH for stimulating the production of the ovum. These treatments are monitored with the help of ultrasound and blood estrogen levels till the eggs become ready to be retrieved and the uterus becomes ready for implantation. Generally, these treatments take around two to three weeks and need five office appointments for processes like ultrasounds and blood tests.
Consequently, IVF and embryo transfer are done
In cycles that are successful, the hormonal supplements are maintained throughout the first trimester (12 weeks) of the gestation. On the conclusion of the first trimester when the placenta matures to the point where it can accommodate all the hormonal demands of the pregnancy, no additional supplements are needed. Blood levels of estrogen and progesterone are monitored at the end of the first trimester and decrease of the hormone supplements slowly. After stopping the hormone supplements, the remaining pregnancy is alike as any other pregnancy!