Why You Might See a False Negative After IVF

Dr. Richika Sahay | 04 Dec 2023 | 161485 Views |

The Rollercoaster of Hope: Why You Might See a False Negative After IVF

Imagine this: you’ve been through the emotional gauntlet of IVF, from the injections to the egg retrieval, the transfer, and the agonizing two-week wait. Finally, pregnancy test day arrives. You hold your breath, pee on the stick, and…negative. Your heart sinks. But wait, could it be a false negative?

Fear not, fellow IVF warriors! False negatives after IVF are more common than you think. It’s not a glitch in the universe, but a complex interplay of hormones, timing, and sometimes, those pesky home pregnancy tests themselves. Let’s untangle this web and give you the knowledge to navigate this emotional rollercoaster.

The Hormone Hurdle:

After an embryo transfer, your body ramps up production of a superhero hormone called hCG (human chorionic gonadotropin). This hCG is the pregnancy test’s target, and it takes time for its levels to reach detectable amounts. Testing too early, even a day or two, can lead to a heartbreaking negative, even if you’re actually pregnant.

Implantation Intricacies:

Implantation, where the embryo snuggles into your uterine lining, is another crucial step. It can take a few days after transfer, and hCG production only starts after successful implantation. So, testing before implantation is even complete sets you up for disappointment.

Test Talk:

Home pregnancy tests are convenient, but they’re not medical grade. Their sensitivity varies, and some might miss the low hCG levels present in early pregnancy, especially after IVF. False negatives are more likely with cheaper tests, so consider investing in a more sensitive brand or opting for a blood test, which can detect hCG much earlier.

What Now? Don’t Panic!

A negative test doesn’t necessarily mean the end of the line. Here’s what to do:

• Retest: Wait 48-72 hours and try another test, preferably a more sensitive one.
• Blood Test: If you’re still unsure, schedule a blood test. It’s the gold standard for early pregnancy detection.
• Talk to your Doctor: They can interpret your hCG levels and offer guidance based on your specific situation.
• Emotional Support: Remember, you’re not alone. Talk to your partner, family, or a therapist. IVF support groups are also invaluable resources.

Remember: A false negative is a possibility, but it doesn’t define your journey. Stay informed, stay hopeful, and most importantly, be kind to yourself. This rollercoaster ride may have a detour, but the destination – parenthood – could still be within reach.

About The Author

Dr. Richika Sahay

MBBS (Gold Medalist), DNB (Obst & Gyne), MNAMS, MRCOG (London-UK), Fellow IVF, Fellow MAS, Infertility (IVF) Specialist & Gynae Laparoscopic surgeon,[Ex AIIMS & Sir Gangaram Hospital, New Delhi]. Read more