Direct Coombs Test

What is DCT?
The direct Coombs test, also called direct antiglobulin test is used to detect antibodies that get attached to the surface of red blood cells. Certain types of diseases and drugs can cause this to happen. These antibodies sometimes destroy red blood cells and lead to anemia.

You may need this test if you have symptoms of anemia and jaundice like yellowing of skin or eyes, weakness & dizziness. A positive Coombs test may indicate autoimmune hemolytic anemia, chronic lymphocytic leukemia, blood disease in new born & transfusion reactions.

Why is DCT done?

1. To screen the recipient of a blood transfusion before the transfusion is done
2. To screen the mother’s blood for antigens that can target the RBCs of the newborn
3. To detect type of anemia
4. To diagnose hemolytic anemia and evaluate if it is caused by autoimmune disease or induced by drugs