Intracytoplasmic sperm injection (ICSI) comprises a solitary active sperm straight inside the middle of the human egg. The method was formed to support increasing the chance of fertilization for couples with harsh male factor infertility or patient who were unsuccessful to achieve fertilization in earlier In Vitro fertilization (IVF) treatment. The process conquers several obstructions to fertilization and grows the chances of fruitful pregnancy to carry out fertilized embryos.
Prior to a male’s sperm make fertilizing a female’s egg; the skull of the sperm must connect to the outer surface of the egg. Once connected, the sperm force via the outer surface to the inside of the egg (cytoplasm), where fertilization happens.
Often the sperm failed to enter the outer surface, due to various reasons. The egg’s out surface might be difficult and wide to infiltrate or the sperm might be failed to float. In these situations, a process known as Intracytoplasmic sperm injection (ICSI) can be performed along with in vitro fertilization (IVF) treatment to support egg’s fertilization. At the time of ICSI, a solitary is injected straight inside the cytoplasm of the egg.
How does ICSI function?
There are 2 methods by that an egg might be fertilized through IVF: conventional and ICSI. In conventional IVF treatment, 50000 and more floating sperm are transferred subsequently to the egg in a laboratory. When one of the sperm penetrates inside the cytoplasm of the egg then fertilization takes place. In the ICSI procedure, a small needle known as a micropipette is utilized to inject a solitary sperm inside the center of the egg. In both conventional IVF and ICSI, once the fertilization takes place, the fertilized egg which is known as the embryo develops in the laboratory prior to infiltrating the women’s womb(uterus).
Why would I need ICSI?
ICSI supports conquering the fertilization chances and eliminating the fertilization complications such as:
When sperm find it difficult to connect to the egg
An obstruction in the male reproductive zone may keep sperm from releasing
Eggs have not fertilized by traditional IVF, regardless of the condition of the sperm.
Earlier frozen eggs are being utilized
When sperm is failed to swim properly or it is abnormal
When males obtain little sperm count to perform artificial insemination (intrauterine insemination [IUI]) or IVF.
When the sperm count is very low
When sperm is recovered through surgical treatment via the epididymis (MESA/PESA) or the testes
If the previous fertilization treatment is failed due to traditional IVF treatment
In case, there are high levels of antibodies present in semen
(TESE/TESA), from urine or subsequent electro-ejaculation
How successful is one cycle of ICSI?
Well, there are many examples and live case study which shows that ICSI is highly successful in supporting sperm and eggs fertilization with 90% success rate. There are several other factors that influence successful pregnancy which includes female infertility and age. The success percentage of ICSI is the same as IVF, so it is hard to tell the exact figure and different statistics.
Is it worth having ICSI even if we don’t have male infertility?
For several people who have no sign of male factor infertility, the possibility of conceiving a baby is similar whether you perform ICSI or not and it will cost you additional if you are paying for your own treatment.
How does ICSI is different from IVF?
The ICSI and IVF treatment is almost the same. But as the name differs, so the difference is obvious., The only difference is that in IVF sperm and eggs are combined and leave them for fertilizing, on the other hand, in ICSI an embryo expert injects a single sperm inside the egg for fertilization.
This increases the possibility of fertilization occurring as it bypasses any possible difficulties the sperm will have in penetrating into the egg.
I’ve had ICSI and it didn’t work – what next?
Similar to IVF, in ICSI, many surgeons suggest that you need to wait for 2 -3 months post-treatment before opting again for the treatment. This will provide you with a break from the tension of treatment and the possibility of your body healing. If you wish, you can opt for ICSI again, only when your doctor sees the possibility that you have a fair chance of success.
However, it is totally your call and you can take your own decision whether to continue the treatment or try other options for getting pregnant such as utilizing adoption and sperm donor.